Project-related publications

Lenz D, Oliver D (2022) Progress in understanding the structural mechanism underlying prestin’s electromotile activity. Hear Res:108423.  In press

“SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans”, Autoren Liu, Xuemei, Seidler, Ursula, Bioguang Tuo. Cellular Oncology in press.

Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation.
Katerina Nikolovska, Li Cao, Inga Hensel, Gabriella Di Stefano,
Anna Elisabeth Seidler, Kunyan Zhou, Jiajie Qian, Anurag Kumar Singh, Brigitte Riederer, Ursula Seidler.
1 January 2022, Acta Physiologica, DOI: 10.1111/apha.13774

Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect.
Archana Kinia, Bei Zhaob, Marijana Basicc, Urmi Royb, Aida Iljazovicb, Ivan Odakd, Zhenghao Yea, Brigitte Riederera, Gabriella Di Stefanoa, Dorothee Römermanna, Christian Koenecked, André Bleichc, Till Strowigb, Ursula Seidler. GUT MICROBES
2022, VOL. 14, NO. 1, e2041943 (18 pages)
doi.org/10.1080/19490976.2022.2041943

A Novel Homozygous KLHL3 Mutation as a Cause of Autosomal Recessive Pseudohypoaldosteronism Type II Diagnosed Late in Life.
Etges A, Hellmig N, Walenda G, Haddad BG, Machtens JP, Morosan T, Rump LC, Scholl UI.
Nephron. 2022 Jan 28:1-11. doi: 10.1159/000521626. Online ahead of print.
PMID: 35093948 Free article.

Hydrokinetic pancreatic function and insulin secretion are
moduled by Cl− uniporter Slc26a9 in mice
T. Li1, G. di Stefano, G. S. Raza, I. Sommerer, B. Riederer,
D. Römermann, X. Tan, Q. Tan, P. Pallagi, M. Hollenbach, K.-H. Herzig, U. Seidler.
4 September 2021, Acta Physiologica, DOI: 10.1111/apha.13729

Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases.
Kostritskii AY, Machtens JP.
Nat Commun. 2021 May 14;12(1):2826. doi: 10.1038/s41467-021-22724-w.
PMID: 33990555 Free PMC article.

g_elpot: A Tool for Quantifying Biomolecular Electrostatics from Molecular Dynamics Trajectories.
Kostritskii AY, Alleva C, Cönen S, Machtens JP.
J Chem Theory Comput. 2021 May 11;17(5):3157-3167. doi: 10.1021/acs.jctc.0c01246. Epub 2021 Apr 29.
PMID: 33914551 Free article.

Chang YN, Jaumann EA, Reichel K, Hartmann J, Oliver D, Hummer G*, Joseph B*, Geertsma ER* (2019) Structural basis for functional interactions in dimers of SLC26 transporters. Nat Commun 10:2032. *shared corresponding authorship. DOI.org/10.1038/s41467-019-10001-w

Kortzak D, Alleva C, Weyand I, Ewers D, Zimmermann MI, Franzen A, Machtens JP*, Fahlke C* (2019) Allosteric gate modulation confers K+ coupling in glutamate transporters. EMBO J: e101468 *shared corresponding authorship. DOI: 10.15252/embj.2019101468 

Geertsma ER*, Chang YN, Shaik FR, Neldner Y, Pardon E, Steyaert J, Dutzler R* (2015) Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat Struct Mol Biol 22:803-808. *shared corresponding authorship. DOI.org/10.1038/nsmb.3091

Machtens JP, Kortzak D, Lansche C, Leinenweber A, Kilian P, Begemann B, Zachariae U, Ewers D, de Groot BL, Briones R, Fahlke C (2015) Mechanisms of anion conduction by coupled glutamate transporters. Cell 160:542-553. DOI.org/10.1016/j.cell.2014.12.035

Gorbunov D, Sturlese M, Nies F, Kluge M, Bellanda M, Battistutta R, Oliver D (2014) Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters. Nat Commun 5:3622. DOI: 10.1038/ncomms4622 

Lissner S, Hsieh CJ, Nold L, Bannert K, Bodammer P, Sultan A, Seidler U, Graeve L and Lamprecht G (2013) The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11apositive recycling endosomes. Am J Physiol Gastrointest Liver Physiol 304:G980-G990. DOI:10.1152/ajpgi.00132.2012.

Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X, Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M, Soleimani M, Seidler U, Mall MA (2012) SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest 122:3629-3634. DOI.org/10.1038/nsmb.3091

Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kugler S, Fakler B, Oliver D (2011) A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity. EMBO J 30:2793-2804. DOI.org/10.1038/emboj.2011.202

Detro-Dassen S, Schanzler M, Lauks H, Martin I, Berstenhorst SMz, Nothmann D, Torres-Salazar D, Hidalgo P, Schmalzing G, Fahlke C (2008) Conserved Dimeric Subunit Stoichiometry of SLC26 Multifunctional Anion Exchangers. J Biol Chem 283:4177-4188. DOI.org/10.1074/jbc.M704924200

Tuo B, Riederer B, Wang Z, Colledge WH, Soleimani M, Seidler U (2006). Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolinstimulated duodenal HCO3- secretion. Gastroenterology 130: 349-358. DOI: 10.1053/j.gastro.2005.10.017