{"id":730,"date":"2025-11-27T10:10:44","date_gmt":"2025-11-27T10:10:44","guid":{"rendered":"https:\/\/slc26-transporters.de\/?page_id=730"},"modified":"2025-11-27T10:39:12","modified_gmt":"2025-11-27T10:39:12","slug":"project-1","status":"publish","type":"page","link":"https:\/\/slc26-transporters.de\/index.php\/project-1\/","title":{"rendered":"Project 1"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\"><strong><strong>Disorder-function relationships in SLC26 transporters<\/strong><\/strong><\/h2>\n\n\n\n<p>The transmembrane gradients of chloride and bicarbonate represent a fundamental and general basis of cellular physiology. Anion transporters of the SLC26 family contribute significantly to their generation and maintenance, as has been extensively demonstrated by their causal involvement in various diseases. The extensive structural and biochemical exploration of the structured regions of SLC26 proteins has greatly improved our understanding of the basic mechanisms underlying transport. However, the role of the more intractable SLC26 domains of low complexity and high disorder, such as the N- and C-terminus and the intervening sequence in the STAS domain, which together can account for over 40% of the total protein mass, has been largely ignored. We expect that these unstructured regions contribute significantly to the function of SLC26 proteins, analogous to their relevance in soluble proteins. We thus aim to assign precise functional roles to the intrinsically disordered regions in SLC26 proteins.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2188\" height=\"2188\" src=\"https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo-.jpg\" alt=\"\" class=\"wp-image-176\" srcset=\"https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo-.jpg 2188w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--300x300.jpg 300w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--1024x1024.jpg 1024w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--150x150.jpg 150w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--768x768.jpg 768w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--1536x1536.jpg 1536w, https:\/\/slc26-transporters.de\/wp-content\/uploads\/2021\/08\/FOR5046_logo--2048x2048.jpg 2048w\" sizes=\"auto, (max-width: 2188px) 100vw, 2188px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Principal Investigator<\/h4>\n\n\n\n<p><a href=\"https:\/\/slc26-transporters.de\/index.php\/persons#geertsma\">Dr. Eric Geertsma<\/a><br><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Disorder-function relationships in SLC26 transporters The transmembrane gradients of chloride and bicarbonate represent a fundamental and general basis of cellular physiology. Anion transporters of the SLC26 family contribute significantly to their generation and maintenance, as has been extensively demonstrated by their causal involvement in various diseases. The extensive structural and biochemical exploration of the structured [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-730","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/comments?post=730"}],"version-history":[{"count":4,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/730\/revisions"}],"predecessor-version":[{"id":768,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/730\/revisions\/768"}],"wp:attachment":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/media?parent=730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}