{"id":55,"date":"2021-07-16T11:49:35","date_gmt":"2021-07-16T11:49:35","guid":{"rendered":"https:\/\/slc26-transporters.de\/?page_id=55"},"modified":"2025-11-25T11:26:55","modified_gmt":"2025-11-25T11:26:55","slug":"publications","status":"publish","type":"page","link":"https:\/\/slc26-transporters.de\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Project-related publications<\/h2>\n\n\n\n

\u2020 — Denotes 1st authorship
\u2021 — Denotes correspondence<\/p>\n\n\n\n

2025<\/h2>\n\n\n\n

N<\/em>-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport<\/strong>
Sophie Achilles, Jan-Niklas Tomczak, Fabiane-Samira Baumann, Bassam G. Haddad, Stefan Oswald, Jan-Philipp Machtens, Eric R. Geertsma, Ilka Wittig, Georg Lamprecht
01 November 2025 — American Journal of Physiology-Gastrointestinal and Liver Physiology<\/strong> — DOI<\/a><\/p>\n\n\n\n

Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4<\/strong>
Andrei Y. Kostritskii\u2021<\/sup>, Yulia Kostritskaia, Natalia Dmitrieva, Jan-Philipp Machtens\u2021<\/sup>
29 April 2025 — PNAS<\/strong> — DOI<\/a><\/p>\n\n\n\n

2024<\/h2>\n\n\n\n

Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA<\/strong>
Benedikt T. Kuhn, Jonathan Z\u00f6ller, Iwan Zimmermann, Tim Gemeinhardt, Dogukan H. \u00d6zkul, Julian D. Langer, Markus A. Seeger, Eric R. Geertsma\u2021<\/sup>
30 August 2024 — Nature Communications<\/strong> — DOI<\/a><\/p>\n\n\n\n

Oligomerization and cellular localization of SLC26A11<\/strong>
Stephanie Bungert-Pluemke, Raul E. Guzman, Christoph Fahlke\u2021<\/sup>
01 May 2024 — BioRxiv<\/strong> — DOI<\/a><\/p>\n\n\n\n

Urinary acid-base excretion deciphers high acid load from colonic bicarbonate loss in intestinal failure patients with ileocolonic anastomosis – Guidance for composition of parenteral support<\/strong>
Robert H. Foerster, Georg Lamprecht\u2021<\/sup>, Karen Rischmueller, Peggy Berlin, Amalie Q. Rousing, Mads V. Sorensen, Jens Leipziger, Peder Berg
29 March 2024 — Clinical Nutrition<\/strong> — DOI<\/a><\/p>\n\n\n\n

Chloride binding and cholesterol effects on high frequency complex nonlinear capacitance (cNLC) in the mouse outer hair cell: experiment and molecular dynamics<\/strong>
Jun-Ping Bai, Chenou Zhang, Vijay Renigunta, Dominik Oliver, Dhasakumar Navaratnam, Oliver Beckstein, Joseph Santos-Sacchi\u2021<\/sup>
31 January 2024 — BioRxiv<\/strong> — DOI (pre-print)<\/a><\/p>\n\n\n\n

Reduced surface pH and upregulated AE2 anion exchange in SLC26A3<\/em>-deleted polarized intestinal epithelial cells<\/strong>
Mahdi Amiri, Min Jiang, Azam Salari, Renjie Xiu, Seth L Alper, and Ursula E. Seidler\u2021<\/sup>
15 January 2024 — American Journal of Physiology: Cell Physiology<\/strong> — DOI<\/a><\/p>\n\n\n\n

2023<\/h2>\n\n\n\n

SLC26 Anion Transporters<\/strong>
Eric R. Geertsma\u2021<\/sup> & Dominik Oliver\u2021<\/sup>
11 November 2023 — Anion Channels and Transporters<\/strong> — DOI<\/a><\/p>\n\n\n\n

Elevator-like movements of prestin mediate outer hair cell electromotility <\/strong>
Makoto F. Kuwabara\u2020<\/sup>, Bassam G. Haddad\u2020<\/sup>, Dominik Lenz-Schwab\u2020<\/sup>, Julia Hartmann\u2020<\/sup>, Piersilvio Longo, Britt-Marie Huckschlag, Anneke Fu\u00df, Annalisa Questino, Thomas K. Berger, Jan-Philipp Machtens\u2021<\/sup>, & Dominik Oliver\u2021<\/sup>
6 November 2023 — Nature Communications<\/strong> — DOI<\/a><\/p>\n\n\n\n

Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome<\/strong>
Khadija El Hindi, Sebastian Brachtendorf, Jennifer C Hartel, Christoph Renn\u00e9, Kerstin Birod, Karin Schilling, Sandra Labocha, Dominique Thomas, Nerea Ferreir\u00f3s, Lisa Hahnefeld, Erika Dorochow, Domenico Del Turco, Thomas Deller, Klaus Scholich, Dominik C Fuhrmann, Andreas Weigert, Bernhard Br\u00fcne, Gerd Geisslinger, Ilka Wittig, Karl-Heinrich Link, Sabine Gr\u00f6sch\u2021<\/sup>
04 October 2023 — Biochimica et Biophysica Acta: Molecular Basis of Disease<\/strong> — DOI<\/a><\/p>\n\n\n\n

The Anion Channel TMEM16a\/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals<\/strong>
Azam Salari, Renjie Xiu, Mahdi Amiri, Sophia Theres Pallenberg, Rainer Schreiber, Anna-Maria Dittrich, Burkhard T\u00fcmmler, Karl Kunzelmann, and Ursula Seidler\u2021<\/sup>
18 September 2023 — International Journal of Molecular Sciences<\/strong> — DOI<\/a><\/p>\n\n\n\n

Expanding the phenotypic and biochemical spectrum of NDUFAF3-related mitochondrial disease<\/strong>
Amelie T van der Ven, Alfredo Cabrera-Orefice, Isabell Wente, Ren\u00e9 G Feichtinger, Konstantinos Tsiakas, Deike Weiss, Tatjana Bierhals, Leila Scholle, Holger Prokisch, Robert Kopajtich, Ren\u00e9 Santer, Johannes A Mayr, Maja Hempel, Ilka Wittig\u2021<\/sup>
10 August 2023 — Molecular Genetics and Metabolism<\/strong> — DOI<\/a><\/p>\n\n\n\n

Dual-color Colocalization in Single-molecule Localization Microscopy to Determine the Oligomeric State of Proteins in the Plasma Membrane<\/strong>
Hua Leonhard Tan\u2021<\/sup>, Stefanie Bungert-Pl\u00fcmke, Daniel Kortzak, Christoph Fahlke, Gabriel St\u00f6lting
5 July 2023 — Bio-Protocol<\/strong> — DOI<\/a><\/p>\n\n\n\n

Domain- and state-specific shape of the electric field tunes voltage sensing in voltage-gated sodium channels<\/strong>
Andrei Kostritskii & Jan-Philipp Machtens\u2021<\/sup>
16 May 2023 — Biophysical Journal<\/strong> — DOI<\/a><\/p>\n\n\n\n

Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor.<\/strong>
Laura Grohs, Linhan Cheng, Saskia C\u00f6nen, Bassam G. Haddad, Astrid B\u00fclow, Idil Toklucu, Lisa Ernst, Jannis K\u00f6rner, G\u00fcnther Schmalzing, Angelika Lampert, Jan-Philipp Machtens and Ralf Hausmann\u2021<\/sup>
16 March 2023 — Frontiers in Pharmacology<\/strong> — DOI<\/a><\/p>\n\n\n\n

Human Colonoid\u2013Myofibroblast Coculture for Study of Apical Na+<\/sup>\/H+<\/sup> Exchangers of the Lower Cryptal Neck Region<\/strong>
Azam Salari, Kunyan Zhou, Katerina Nikolovska, Ursula Seidler\u2021<\/sup>, and Mahdi Amiri\u2021<\/sup>
21 February 2023 — International Journal of Molecular Sciences<\/strong> — DOI<\/a><\/p>\n\n\n\n

2022<\/h2>\n\n\n\n

Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling<\/strong>
Jonathan Schiller, Eike Laube, Ilka Wittig, Werner K\u00fchlbrandt, Janet Vonck, and Volker Zickermann\u2021<\/sup>
06 November 2022 — Science Structural Biology<\/strong> — DOI<\/a> <\/p>\n\n\n\n

Dual-color Colocalization in Single-molecule Localization Microscopy to Determine the Oligomeric State of Proteins in the Plasma Membrane.<\/strong>
Hua Leonhard Tan, Stefanie Bungert-Pl\u00fcmke, Daniel Kortzak, Christoph Fahlke, and Gabriel St\u00f6lting\u2021<\/sup>
07 October 2022 — eLife<\/strong> — DOI<\/a><\/p>\n\n\n\n

Progress in understanding the structural mechanism underlying prestin’s electromotile activity.<\/strong>
Dominik Lenz-Schwab & Dominik Oliver\u2021<\/sup>
15 September 2022 — Hearing Research<\/strong> — DOI<\/a><\/p>\n\n\n\n

The NHE3 Inhibitor Tenapanor Prevents Intestinal Obstructions in CFTR-Deleted Mice<\/strong>
Xinjie Tan, Archana Kini, Dorothee R\u00f6mermann, Ursula Seidler\u2021<\/sup>
1 September 2022 — International Journal of Molecular Sciences<\/strong> — DOI<\/a><\/p>\n\n\n\n

SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.<\/strong>
Xuemei Liu, Ursula Seidler, BioGuang Tuo\u2021<\/sup>
14 April 2022 — Cellular Oncology<\/strong> — DOI<\/a><\/p>\n\n\n\n

Upregulation of antimicrobial peptide expression in slc26a3-\/- mice with colonic dysbiosis and barrier defect.<\/strong>
Archana Kinia, Bei Zhaob, Marijana Basicc, Urmi Royb, Aida Iljazovicb, Ivan Odakd, Zhenghao Yea, Brigitte Riederera, Gabriella Di Stefanoa, Dorothee R\u00f6mermanna, Christian Koenecked, Andr\u00e9 Bleichc, Till Strowigb, Ursula Seidler\u2021<\/sup>
01 March 2022 — Gut Microbes<\/strong> — DOI<\/a><\/p>\n\n\n\n

A Novel Homozygous KLHL3 Mutation as a Cause of Autosomal Recessive Pseudohypoaldosteronism Type II Diagnosed Late in Life.<\/strong>
Annika Etges, Nicole Hellmig, Gudrun Walenda, Bassam G. Haddad, Jan-Philipp Machtens, Thomas Morosan, Lars Christian Rump, Ute I. Scholl\u2021<\/sup>
28 January 2022 — Nephron<\/strong> — DOI<\/a><\/p>\n\n\n\n

Sodium\/hydrogen-exchanger-2 modulates colonocyte lineage differentiation.<\/strong>
Katerina Nikolovska, Li Cao, Inga Hensel, Gabriella Di Stefano,
Anna Elisabeth Seidler, Kunyan Zhou, Jiajie Qian, Anurag Kumar Singh, Brigitte Riederer, Ursula Seidler\u2021<\/sup>
1 January 2022 — Acta Physiologica<\/strong> — DOI<\/a><\/p>\n\n\n\n

2021<\/h2>\n\n\n\n

Aging of Podospora anserina<\/em> Leads to Alterations of OXPHOS and the Induction of Non-Mitochondrial Salvage Pathways<\/strong>
Verena Warnsmann, Jana Meisterknecht, Ilka Wittig and Heinz D. Osiewacz\u2021<\/sup>
26 November 2021 — Cells<\/strong> — DOI<\/a><\/p>\n\n\n\n

Hydrokinetic pancreatic function and insulin secretion are
moduled by Cl\u2212 uniporter Slc26a9 in mice<\/strong>
Taolang Li, Gabriella di Stefano, Ghulam S. Raza, Ines Sommerer, Brigitte Riederer, Dorothee R\u00f6mermann, Xinjie Tan, Qinghai Tan, Petra Pallagi, Marcus Hollenbach, Karl-Heinz Herzig, Ursula Seidler\u2021<\/sup>
04 September 2021 — Acta Physiologica<\/strong> — DOI<\/a><\/p>\n\n\n\n

Complexome Profiling: Assembly and Remodeling of Protein Complexes<\/strong>
Ilka Wittig\u2021<\/sup> and Pedro Felipe Malacarne
21 July 2021 — International Journal of Molecular Sciences<\/strong> — DOI<\/a><\/a><\/p>\n\n\n\n

Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases.<\/strong>
Andrei Kostritskii & Jan-Philipp Machtens\u2021<\/sup>
14 May 2021 — Nature Communications<\/strong> — DOI<\/a><\/p>\n\n\n\n

g_elpot: A Tool for Quantifying Biomolecular Electrostatics from Molecular Dynamics Trajectories.<\/strong>
Andrei Kostritskii, Claudia Alleva, Saskia C\u00f6nen, Jan-Philipp Machtens\u2021<\/sup>
11 May 2021 — Journal of Chemical Theory & Computation<\/strong> — DOI<\/a><\/p>\n\n\n\n

2020<\/h2>\n\n\n\n

Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells<\/strong>
Thomas Effertz, Tobias Moser\u2021<\/sup>, Dominik Oliver\u2021<\/sup>
21 December 2020 — H1 Connect<\/strong> — DOI<\/a><\/p>\n\n\n\n

2019<\/h2>\n\n\n\n

Allosteric gate modulation confers K+ coupling in glutamate transporters<\/strong>
Daniel Kortzak, Claudia Alleva, Ingo Weyand, David Ewers, Meike I Zimmermann, Arne Franzen, Jan-Philipp Machtens\u2021<\/sup>, Christoph Fahlke\u2021<\/sup>
10 September 2019 — The EMBO Journal<\/strong> — DOI<\/a><\/p>\n\n\n\n

Structural basis for functional interactions in dimers of SLC26 transporters.<\/strong>
Yung-Ning Chang\u2020<\/sup>, Eva A. Jaumann\u2020<\/sup>, Katrin Reichel\u2020<\/sup>, Julia Hartmann, Dominik Oliver, Gerhard Hummer\u2021<\/sup>, Benesh Joseph\u2021<\/sup>, Eric R. Geertsma\u2021<\/sup>
02 May 2019 — Nature Communications<\/strong> — DOI<\/a><\/p>\n\n\n\n

2015<\/h2>\n\n\n\n

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family<\/strong>
Eric R. Geertsma\u2021<\/sup>, Yung-Ning Chang, Farooque R. Shaik, Yvonne Neldner, Els Pardon, Jan Steyaert, Raimund Dutzler\u2021<\/sup>
14 September 2015 — Nature Structural & Molecular Biology<\/strong> — DOI<\/a><\/p>\n\n\n\n

Mechanisms of anion conduction by coupled glutamate transporters. <\/strong>
Jan-Philipp Machtens, Daniel Kortzak, Christine Lansche, Ariane Leinenweber, Petra Kilian, Birgit Begemann, Ulrich Zachariae, David Ewers, Bert L. de Groot, Rodolfo Briones, Christoph Fahlke\u2021<\/sup>
29 January 2015 — Cell<\/strong> — DOI<\/a><\/p>\n\n\n\n

2014<\/h2>\n\n\n\n

Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters.<\/strong>
Dmitry Gorbunov, Mattia Sturlese, Florian Nies, Murielle Kluge, Massimo Bellanda, Roberto Battistutta, Dominik Oliver\u2021<\/sup>
08 April 2014 — Nature Communications<\/strong> — DOI<\/a><\/p>\n\n\n\n

2013<\/h2>\n\n\n\n

The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11apositive recycling endosomes.<\/strong>
Simone Lissner, Chih-Jen Hsieh, L Nold, Karen Bannert, Peggy Bodammer, Ahmed Sultan, Ursula Seidler, Lutz Graeve and Georg Lamprecht\u2021<\/sup>
11 April 2013 — American Journal of Physiology: Gastrointestinal and Liver Physiology<\/strong> — DOI<\/a><\/p>\n\n\n\n

2012<\/h2>\n\n\n\n

SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.<\/strong>
Pinelopi Anagnostopoulou, Brigitte Riederer, Julia Duerr, Sven Michel, Aristea Binia, Raman Agrawal, Xuemei Liu, Katrin Kalitzki, Fang Xiao, Mingmin Chen, Jolanthe Schatterny, Dorothee Hartmann, Thomas Thum, Michael Kabesch, Manoocher Soleimani, Ursula Seidler\u2021<\/sup>, and Marcus A. Mall\u2021<\/sup>
04 September 2012 — The Journal of Clinical Investigation <\/strong>— DOI<\/a><\/p>\n\n\n\n

2011<\/h2>\n\n\n\n

A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.<\/strong>
Thorsten J. Schaechinger, Dmitry Gorbunov, Christian R. Halaszovich, Tobias Moser, Sebastian Kugler, Bernd Fakler, Dominik Oliver\u2021<\/sup>
24 June 2011 — The EMBO Journal<\/strong> — DOI<\/a><\/p>\n\n\n\n

2008<\/h2>\n\n\n\n

Conserved Dimeric Subunit Stoichiometry of SLC26 Multifunctional Anion Exchangers.<\/strong>
Silvia Detro-Dassen, Michael Schanzler, Heike Lauks, Ina Martin, Sonja Meyer zu Berstenhorst, Doreen Nothmann, Delany Torres-Salazar, Patricia Hidalgo, G\u00fcnther Schmalzing G, Christoph Fahlke
15 February 2008 — Journal of Biological Chemistry<\/strong> — DOI<\/a><\/p>\n\n\n\n

2007<\/h2>\n\n\n\n

Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolinstimulated duodenal HCO3- secretion.<\/strong>
BiGuang Tuo, Brigitte Riederer, Zhaohui Wang, William H. Colledge, Manoocher Soleimani, Ursula Seidler
2 February 2006 — Gastroenterology<\/strong> — DOI<\/a><\/p>\n<\/div>\n\n\n\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

Project-related publications \u2020 — Denotes 1st authorship\u2021 — Denotes correspondence 2025 N-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transportSophie Achilles, Jan-Niklas Tomczak, Fabiane-Samira Baumann, Bassam G. Haddad, Stefan Oswald, Jan-Philipp Machtens, Eric R. Geertsma, Ilka Wittig, Georg Lamprecht01 November 2025 — […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-55","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/55","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/comments?post=55"}],"version-history":[{"count":49,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/55\/revisions"}],"predecessor-version":[{"id":711,"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/pages\/55\/revisions\/711"}],"wp:attachment":[{"href":"https:\/\/slc26-transporters.de\/index.php\/wp-json\/wp\/v2\/media?parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}